The following paper culminates a year of research conducted by researchers at E[superscript 3] Alliance and Texas State University and sponsored by the National Science Foundation. The following reports on promising practices observed and reported at Manor New Tech High School (MNTH), a Texas Science Technology Engineering Mathematics (T-STEM) high school in Manor Independent School District (ISD) that opened in August 2007. MNTH follows several high school redesign principles such as small learning communities and rigorous coursework with real-world applications, and is focused on Science, Technology, Engineering, and Mathematics (STEM). Through a case study analysis based on teacher surveys, interviews, and site visits, the researchers identify practices that potentially apply to comprehensive high schools committed to improving student outcomes in STEM fields.