High school is a time of changes in adolescents' physical, psychological, social, and sexual development, often resulting in stress and anxiety. Adolescents are particularly vulnerable to mental health problems. Yoga is an Indian discipline practiced globally for health and relaxation. School-based yoga programs are becoming increasingly common given their potential benefits for high-school students. We conducted a literature review of studies of high school-based yoga programs, focusing on the reported benefits for adolescents. We identified 22 studies retrieved from electronic databases including Education Resources Information Center, PsycINFO, and Google Scholar that met inclusion criteria; (1) examined the benefits of yoga as the primary intervention conducted in a high school setting with students ages 14 to 19 years old; (2) was published by 2020; (3) was reviewed either by a journal editorial board or by a student's dissertation committee; (4) was available in English; and (5) a full text copy was available. Results of studies were synthesized by clustering study findings into common domains. High school-based yoga showed promise in terms of physical, social, academic, and mental health benefits for students. Yoga also showed benefits for high students who were stressed, anxious, or depressed, or those at risk for abusing substances or dropping out of school. We provide recommendations from the literature for those contemplating the implementation of yoga in high schools.