Objectives: This article identifies salient components in the advancement of social work research leadership within health care. Method: Using tenets of a modified retrospective case study approach, processes and outcomes of social work research progression at a pediatric hospital are reviewed. Results: Capacity-building processes were implemented. These processes generally corresponded with clinical, research, and administrative priorities and strategically aligned with social work aims of evidence-based practice and research leadership. Elements contributing to improved capacity include clarity of vision, palatable funding models, and the infusion of PhD-trained researchers within the clinical setting. Conclusions: This case study argues for social work to be proactive knowledge leaders. Such an aim, however, inherently requires deliberate shepherding, including strategies to advance the profession. (Contains 1 figure.)