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Direct linkDaly, Caitlin H.; Maconachie, Ross; Ades, A. E.; Welton, Nicky J. – Research Synthesis Methods, 2022
Randomised controlled trials of cancer treatments typically report progression free survival (PFS) and overall survival (OS) outcomes. Existing methods to synthesise evidence on PFS and OS either rely on the proportional hazards assumption or make parametric assumptions which may not capture the diverse survival curve shapes across studies and…
Descriptors: Nonparametric Statistics, Randomized Controlled Trials, Evidence, Networks
Kosch, Robin; Jung, Klaus – Research Synthesis Methods, 2019
Research synthesis, eg, by meta-analysis, is more and more considered in the area of high-dimensional data from molecular research such as gene and protein expression data, especially because most studies and experiments are performed with very small sample sizes. In contrast to most clinical and epidemiological trials, raw data are often…
Descriptors: Genetics, Meta Analysis, Molecular Structure, Scientific Research
Hoyer, Annika; Hirt, Stefan; Kuss, Oliver – Research Synthesis Methods, 2018
Systematic reviews and meta-analyses are the cornerstones of evidence-based medicine and inform treatment, diagnosis, or prevention of individual patients as well as policy decisions in health care. Statistical methods for the meta-analysis of intervention studies are well established today. Meta-analysis for diagnostic accuracy trials has also…
Descriptors: Medicine, Evidence Based Practice, Research Methodology, Meta Analysis
