Research suggests that early self-regulatory difficulties among high-risk newborns can lead to poor interactional difficulties and negative long-term cognitive and social-emotional outcomes if not identified and treated early. This article describes why an individualized, developmentally supportive, relationship-based program, such as the Newborn Behavioral Observations (NBO) system, should be standard of care and how to implement such programming for high-risk newborns and their families. The NBO is an intervention that helps parents of newborns read their baby's self-regulatory cues with the goal of promoting parent-infant interaction and infant development.