This monograph focuses on school-based practices and programs that promote safe and drug-free schools. It begins with a description of the key characteristics of schools with effective programs and provides a model for school-wide support. Necessary steps for developing an effective system of universal prevention are listed and include: (1) establish a climate of mutual respect; (2) conduct a review of all policies related to safety, instruction, and student discipline; (3) recognize feelings of staff and students and what constitutes appropriate expressions of those feelings; (4) make identifying and managing feelings an integral part of the curriculum; (5) teach the concept of responsibility for ones actions throughout the curriculum; (6) recognize and intervene when early warning signs are observed; (7) implement programs to prevent alcohol and substance abuse; (8) train staff in topics such as diversity problem-solving skills, verbal de-escalation, cooperative learning, anger control, and aggression management; (9) avoid legal vulnerability; and (10) couple security procedures with a school-wide communication system and a crisis plan. Following chapters address the academic/behavior connection, the concept of a school-wide team to address prevention and intervention, and guidelines for selecting programs. Five specific programs are described and a list of additional resources is provided. (CR)