This document is a comprehensive directory of Federal offices, programs, and facilities for K-12 education in mathematics and science for the Mid-Continent Region. The purpose of this directory is to assist educators, parents, and students in attaining the National Education Goals, particularly Goal 4: "By the year 2000, U.S. students will be first in the world in science and mathematics achievement." The guidebook describes programs, along with contact information, that assist students who will go on to study in college or technical school, as well as programs to improve general mathematical and scientific literacy. The directory is divided into three sections. Section One: Agency Overviews contains general information about each of the 16 federal agencies that collaborated with the Eisenhower National Clearinghouse to produce this publication. Each agency highlights its involvement in mathematics and science education and acquaints the reader with agency-specific background information. Each agency also lists is administrative offices for mathematics and science education to give readers a source for additional information on its organization and operation. Section Two: National Programs for Elementary and Secondary Education features nationwide agency-sponsored mathematics and science programs. Each program entry includes the program name, a brief program description, and contact information. Section Three: Regional Highlights lists, within state groupings, agency resources that are available in the Mid-Continent Region, which includes Colorado, Kansas, Missouri, Nebraska, North Dakota, South Dakota, and Wyoming. The document concludes with an index of teacher programs; student programs; comprehensive programs; evaluation, dissemination, and technical assistance programs; and educational technology programs. (MKR)