Borrowing the term "translational research" (TR) from medicine, along with some of the ideas and practices that define it, holds promise as a way of linking research more closely to the practice of youth development. However, doing so entails substantial adaptation. TR is more than a new name for applied research. It comprehends the sequence of very different kinds of research that connect new knowledge with practice and ultimately with enhanced youth development. Research syntheses and evidence-based programs and practices are central to TR, which draws on a variety of research methods and traditions, including epidemiology, "basic" research, evaluation, and implementation science. Syntheses are needed in all these areas along with communication among researchers representing them as well as with practitioners. The flow of information is bi-directional; research is informed by practice and practitioners conduct research.