When science is integrated into early childhood learning experiences, it becomes a critical area supporting young children's development. Young children are natural scientists, curious about their world, and they engage in scientific practices to learn about and explore their world. This article describes how the K-12 Framework for Science Education can and should be tailored and applied to early childhood to align science learning from infancy through 12th grade. Further, the Framework provides a coherent structure for children to build the complexity of their understanding of science across the early years and beyond. The authors highlight the role that adults play, illustrate application of the framework, and demonstrate how high-quality science interactions not only build the foundation for later science learning but also support development across multiple readiness domains.