This report summarizes key indicators that assess the status of the science and engineering (S&E) enterprise within the United States and that illustrate the U.S. global position in multiple aspects of the S&E enterprise. This includes information about the geographic distribution of S&E activities; science, technology, engineering, and mathematics (STEM) employment opportunities; geographic differences in STEM education; and the participation of demographic and socioeconomic groups in the S&E enterprise within the United States. This report provides high-level findings from detailed analyses in nine thematic reports that together make up "Science and Engineering Indicators 2022." The thematic reports rely on publicly available data, surveys performed by the National Center for Science and Engineering Statistics (NCSES) within the National Science Foundation (NSF), and surveys and analysis performed by a range of other federal and international organizations. Here, selected data from the nine reports are grouped into three major sections, and notes at the end of the report provide information about the specific reports that are the sources for each section. The first section describes the U.S. STEM education system from K-12 through doctoral level education and the STEM workforce, including the international composition of S&E degree-seeking students and the contribution of foreign-born workers. The second section is on R&D, which provides analysis of how various economic sectors fund and perform R&D activities and compares the United States to other top R&D-performing countries. This section also includes two sidebars: one on the revisions to the global R&D estimates and one on the effects of the COVID-19 pandemic on the U.S. S&E enterprise. The final section focuses on outputs of the S&E enterprise to provide insight into how U.S. S&E contributes to global knowledge, innovation, and products of knowledge- and technology-intensive (KTI) industries. Highlighting the global nature of the use of these outputs, this section focuses on comparisons between the United States and other major contributing regions, countries, or economies. [SRI International, Center for Innovation Strategy and Policy, assisted with report preparation. For the previous edition of this report (2020), see ED604762.]