Challenging behaviors of students with autism spectrum disorder (ASD) may occur for a variety of reasons. These behaviors can contribute to the emotional burnout of teachers and impact the learning and safety of the student with ASD and his or her classmates. Physical education is one educational context where high and multiple risks of challenging behaviors may occur due to its unique characteristics compared to other subject areas (e.g., natural stimuli in the gymnasium, variety of equipment, need for physical assistance). The purpose of this article is to address several possible reasons why students with ASD demonstrate challenging behaviors, and to provide strategies for physical educators to minimize these behaviors.