We collected think-aloud and posttest data from 60 undergraduates to examine whether they used different proportions of self-regulated learning (SRL) variables in two related learning tasks about science topics while using a hypermedia environment. We also manipulated the goal structure of the two hypermedia learning tasks to explore whether the goal structure of the learning task is related to the use of SRL variables. Participants were randomly assigned to one of three conditions (mastery goal structure, performance-approach goal structure, or performance-avoidance goal structure) and participated in two 20-minute learning tasks in which they used hypermedia to learn about the circulatory system in one learning task and the respiratory system in another learning task. Results indicate that a mastery goal structure and a performance-approach goal structure are related to undergraduates' use of similar proportions of SRL variables in two hypermedia learning tasks, whereas a performance-avoidance goal structure is related to undergraduate's use of different proportions of SRL variables, specifically "planning," in two similar hypermedia learning tasks. Based on these results, the implications for the design of hypermedia learning environments are discussed.