Lesbian, gay, bisexual, and questioning (LGBQ) persons come from diverse cultural groups with diverse racial and ethnic identities. However, most research on LGBQ persons has used primarily White samples, and most research on African Americans has used largely heterosexual samples. Thus, research has largely failed to attend to and investigate the complexity of African American LGBQ persons' experiences. This study examined the relations between multiple internalized oppressions and African American sexual minority persons' self-esteem and psychological distress. Results indicated that when examined together, internalized racism and internalized heterosexism (also known as internalized homophobia) were both significant negative predictors of self-esteem, but only internalized heterosexism was a unique positive predictor of psychological distress. The interaction of internalized racism and internalized heterosexism was not a significant predictor of self-esteem or psychological distress. Finally, the authors' findings indicate that self-esteem partially mediates the relationship between internalized heterosexism and psychological distress. (Contains 2 tables and 1 figure.)