Research demonstrates that there is a gap in focusing understanding factors of information communication technology (ICT) acceptance and use in small and medium enterprises (SMEs). ICT is gaining popularity because it is a force in the economic growth equation. SMEs adopt ICT to promote their business strategy, performance, and growth. This study focused on the factors influencing ICT acceptance and use in SMEs. The research questions were 1) what factors influence SME owners/managers to accept ICT in Kenya? 2) What is the relationship between ICT acceptance and SMEs retail business growth in Kenya? and 3) What is the relationship between ICT usage and SMEs retail business growth in Kenya? The researcher used quantitative research methodology to survey SME owners/managers in Kenya. The researcher hand delivered the survey to 121 potential participants, of which 118 responded. This study evaluated factors of ICT acceptance in SMEs, the relationship between ICT acceptance and SME growth, and the relationship between ICT usage and SME growth. Research findings showed that customer services, cost reduction and business relationships were the most influential factors of ICT acceptance. Computer applications and mobile phones were the most commonly used ICT tools. The study found a strong positive relationship between ICT acceptance and SME growth, and a moderate positive relationship between ICT usage and SME growth. The research results are valuable to stakeholders including potential entrepreneurs, sponsors, government official and financial institutions who make informed decision and formulate policies about ICT investment and effective business strategies for SMEs growth. [The dissertation citations contained here are published with the permission of ProQuest LLC. Further reproduction is prohibited without permission. Copies of dissertations may be obtained by Telephone (800) 1-800-521-0600. Web page: http://www.proquest.com/en-US/products/dissertations/individuals.shtml.]