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Jin, Iksung; Kassabov, Stefan; Kandel, Eric R.; Hawkins, Robert D. – Learning & Memory, 2021
Most studies of molecular mechanisms of synaptic plasticity have focused on the sequence of changes either at individual synapses or in the cell nucleus. However, studies of long-term facilitation at "Aplysia" sensory neuron--motor neuron synapses in isolated cell culture suggest two additional features of facilitation. First, that there…
Descriptors: Animals, Neurological Organization, Molecular Structure, Physiology
Jin, Iksung; Kandel, Eric R.; Hawkins, Robert D. – Learning & Memory, 2011
Whereas short-term plasticity involves covalent modifications that are generally restricted to either presynaptic or postsynaptic structures, long-term plasticity involves the growth of new synapses, which by its nature involves both pre- and postsynaptic alterations. In addition, an intermediate-term stage of plasticity has been identified that…
Descriptors: Animals, Biochemistry, Neurological Organization
Huang, Yan-You; Kandel, Eric R. – Learning & Memory, 2006
Protein synthesis-dependent late phase of LTP (L-LTP) is typically induced by repeated high-frequency stimulation (HFS). This form of L-LTP is reduced in the aged animal and is positively correlated with age-related memory loss. Here we report a novel form of protein synthesis-dependent late phase of LTP in the CA1 region of hippocampus induced by…
Descriptors: Young Adults, Stimulation, Animals, Memory
Alarcon, Juan M.; Hodgman, Rebecca; Theis, Martin; Huang, Yi-Shuian; Kandel, Eric R.; Richter, Joel D. – Learning & Memory, 2004
CPEB-1 is a sequence-specific RNA binding protein that stimulates the polyadenylation-induced translation of mRNAs containing the cytoplasmic polyadenylation element (CPE). Although CPEB-1 was identified originally in Xenopus oocytes, it has also been found at postsynaptic sites of hippocampal neurons where, in response to N-methyl-D-aspartate…
Descriptors: Molecular Structure, Brain, Stimulation, Depression (Psychology)
Till, Sally M.; Li, Hsiu-Ling; Miniaci, Maria Concetta; Kandel, Eric R.; Choi, Yun-Beom – Learning & Memory, 2011
Loss of the Fragile X mental retardation protein (FMRP) is associated with presumed postsynaptic deficits in mouse models of Fragile X syndrome. However, the possible presynaptic roles of FMRP in learning-related plasticity have received little attention. As a result, the mechanisms whereby FMRP influences synaptic function remain poorly…
Descriptors: Mental Retardation, Long Term Memory, Depression (Psychology), Cognitive Processes