In 2006, the Hawai'i State Department of Health (DOH) received the Strategic Prevention Framework State Incentive Grant (SPF-SIG) from the Substance Abuse and Mental Health Services Administration (SAMHSA) to establish a comprehensive, coordinated, and sustainable substance abuse prevention infrastructure in Hawai'i. The SPF-SIG Project is funded for five years with approximately two million dollars per year, administered by the Alcohol and Drug Abuse Division (ADAD) of the DOH. This progress report describes the SPF-SIG Project, examines the process-development indicators, and presents the project's achievements and challenges in the past four years ending September 2010. (Contains 13 figures and 3 tables.)