Collaborative information sharing tends to be highly dynamic and often ad hoc among organizations. The dynamic natures and sharing patterns in ad-hoc collaboration impose a need for a comprehensive and flexible approach to reflecting and coping with the unique access control requirements associated with the environment. This dissertation outlines a Role-based Access Management for Ad-hoc Resource Sharing framework (RAMARS) to enable secure and selective information sharing in the heterogeneous ad-hoc collaborative environment. Our framework incorporates a role-based approach to addressing originator control, delegation and dissemination control. A special trust-aware feature is incorporated to deal with dynamic user and trust management, and a novel resource modeling scheme is proposed to support fine-grained selective sharing of composite data. As a policy-driven approach, we formally specify the necessary policy components in our framework and develop access control policies using standardized eXtensible Access Control Markup Language (XACML). The feasibility of our approach is evaluated in two emerging collaborative information sharing infrastructures: peer-to-peer networking (P2P) and Grid computing. As a potential application domain, RAMARS framework is further extended and adopted in secure healthcare services, with a unified patient-centric access control scheme being proposed to enable selective and authorized sharing of Electronic Health Records (EHRs), accommodating various privacy protection requirements at different levels of granularity. [The dissertation citations contained here are published with the permission of ProQuest LLC. Further reproduction is prohibited without permission. Copies of dissertations may be obtained by Telephone (800) 1-800-521-0600. Web page: http://www.proquest.com/en-US/products/dissertations/individuals.shtml.]