Background: The classroom is a social system in which the teacher and the students interact as organizational members. The quality of classroom relations is dependent on the activities of both the instructor and the students. Several environmental conditions and circumstances often tend to either improve or depress the academic performances of students in defiance of their natural academic endowments. Aim: This study was to identify the relationship between teacher-students' interpersonal relationships and students' academic achievements in social studies. Methods: The work used the "ex post facto" design and a sample of 1954 Junior Secondary School (JSS) III randomly drawn from 50 Government Secondary Schools in Calabar Educational Zone of Cross River State, Nigeria. Two instruments were used: The Teacher-Students' Relationship Questionnaire and a 50-item multiple choice questions in social studies set using the JSS social studies syllabus and validated by test experts. The data were analysed using the Pearson product moment correlation analysis (r). Product moment correlation analysis (r) is used in finding the relationship between two variables "X" and "Y", if these variables are continuous and are obtained from the sample. Outcomes: There was a significant relationship between teacher-students' interpersonal relationship and students' academic achievements in social studies. As a researcher, this means much for me. Students themselves are classroom observers. They are aware, to a great extent, of their own academic standing in the classroom as well as those of others. Some examples of the strategies students use to evaluate their own academic standing include the tasks they are given, grouping strategies implemented in the classroom (e.g. ability grouping) teacher feedback and information regarding ability, the responsibilities that teachers provide students with and the quality of teacher-students relationships. Conclusions: The major conclusion forwarded by this research was that there was a significant relationship between the teacher-students' interpersonal relationship and students' academic performances in social studies. This has a serious implication for me and others, viz, a good human relationship is one of the lubricants of high productivity. Teachers should therefore galvanize cordial relations between themselves and students. All teachers, including this researcher, should bear in mind that a healthy interpersonal relationship is one indispensable instrument of high productivity and achievement in all fields of human endeavour including the education industry. (Contains 1 table.)