This article provides a broad overview of the history of career-focused education in the United States and the reauthorization of the federal Carl D. Perkins Career and Technical Education Improvement Act of 2006. The Perkins act required that the recipients of its funding offer at least one program of study, and this reauthorization included four core components that play a central role in the implementation of the overall Programs of Study initiative. As such, we provide a background of the development of the Programs of Study initiative in Perkins through earlier initiatives: Tech Prep, career pathways, youth apprenticeship, and dual/concurrent-credit programs. We also offer a brief overview of the challenges faced by each initiative, along with an overview of the three National Research Center for Career and Technical Education longitudinal studies represented in this special issue. (Contains 3 notes.)