ERIC Number: EJ749830
Record Type: Journal
Publication Date: 2006-Jan
Pages: 5
Abstractor: Author
ISBN: N/A
ISSN: ISSN-0021-9584
EISSN: N/A
Secondary Structure Switch
King, Angela G.
Journal of Chemical Education, v83 n1 p10-14 Jan 2006
Neurogenerative diseases like Alzheimer's disease and Parkinson's disease involve a transformation between two peptide and protein structures of alpha-helices and beta-sheets, where the peptide backbone can also participate in metal ion binding in addition to histidine residues. However, the complete absence of change in conformation of Coiled Coil upon addition of metal ions reveal the importance of metal complexation by histidine as a trigger mechanism.
Descriptors: Alzheimers Disease, Neurological Impairments, Structural Analysis (Science), Organic Chemistry, Brain, Diseases
Division of Chemical Education of the American Chemical Society. Subscription Department, P.O. Box 1267, Bellmawr, NJ 08099-1267. Tel: 800-691-9846; Tel: 856-931-5825; Fax: 856-931-4115; e-mail: jchemed@egpp.com; Web site: http://jchemed.chem.wisc.edu/
Publication Type: Journal Articles; Reports - Descriptive
Education Level: N/A
Audience: N/A
Language: English
Sponsor: N/A
Authoring Institution: N/A
Grant or Contract Numbers: N/A