The introduction of pen-enabling devices has been demonstrated to increase a student's ability to solve problems, communicate, and learn during note taking. For the science, technology, engineering, and mathematics subjects that are considered to be symbolic in nature, pen interfaces are better suited for visual-spatial content and also provide a better interface to support human expression. The approach described herein is the adoption of an innovative Technology Enhanced Learning (TEL) pedagogy to enable delivery of chemistry lectures through OneNote, offering real-time annotation of notes delivered directly to student's personal devices. The TEL innovation adopts the use of Cloud-based teaching methodologies (Microsoft OneDrive), the use of high-fidelity digital pen technology (Surface Pro), and standard Microsoft products (OneNote 2016), which are not specialized, to support the learning pedagogy. The motivation was to enhance the student teaching and learning experience while offering a single delivery system for the lecturer. For the lecturer, OneNote offers a one-stop-shop for those who use different source materials, and all lecture material is available via a OneDrive Cloud.