ERIC Number: EJ882640
Record Type: Journal
Publication Date: 2010-Jun
Abstractor: As Provided
mRNA and Protein Levels for GABA[subscript A][alpha]4, [alpha]5, [beta]1 and GABA[subscript B]R1 Receptors are Altered in Brains from Subjects with Autism
Fatemi, S. Hossein; Reutiman, Teri J.; Folsom, Timothy D.; Rooney, Robert J.; Patel, Diven H.; Thuras, Paul D.
Journal of Autism and Developmental Disorders, v40 n6 p743-750 Jun 2010
We have shown altered expression of gamma-aminobutyric acid A (GABA[subscript A]) and gamma-aminobutyric acid B (GABA[subscript B]) receptors in the brains of subjects with autism. In the current study, we sought to verify our western blotting data for GABBR1 via qRT-PCR and to expand our previous work to measure mRNA and protein levels of 3 GABA[subscript A]) subunits previously associated with autism (GABR[alpha]4; GABR[alpha]5; GABR[beta]1). Three GABA receptor subunits demonstrated mRNA and protein level concordance in superior frontal cortex (GABR[alpha]4, GABR[alpha]5, GABR[beta]1) and one demonstrated concordance in cerebellum (GABBR1). These results provide further evidence of impairment of GABAergic signaling in autism.
Descriptors: Autism, Brain, Brain Hemisphere Functions, Neurological Impairments, Neurological Organization, Inhibition, Genetics, Behavior Problems
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Publication Type: Journal Articles; Reports - Research
Education Level: N/A
Authoring Institution: N/A