Transforming science curricula into multicultural science curricula requires the infusion of materials and perspectives often omitted from classroom textbooks. One strategy that may help the development of such lessons is to design lessons that incorporate the cultural history behind the concept being taught. Presented in this article is a four-day science unit on Spanish moss, its cultural uses, physiology, geographical distribution, and survival adaptations. The study of Spanish moss, a practical specimen, can help synthesize various scientific concepts. (Contains 2 figures.)