Science and mathematics education in Ireland is facing an increasing number of challenges due to economic and social change. Some of these challenges mirror international trends while others are unique to the Irish education system. In order to meet the demands that are being placed on science and mathematics education in Ireland at post-primary level, the time might be right for the implementation and support of university-based interventions. This paper describes an inquiry-based learning intervention for post-primary students that seek to sustain and nurture student interest in science, technology, engineering and mathematics. The intervention is an example of how institutions of higher education can support post-primary students by giving them the confidence needed to face the challenges of a 21st century society.