Cross-cultural mentoring involves an ongoing, intentional, and mutually enriching relationship with someone of a different race, gender, ethnicity, religion, cultural background, socioeconomic background, sexual orientation, or nationality. Generally more experienced, the cross-cultural mentor guides the intellectual and personal development of the mentee over time. At its best, this relationship is built on a foundation of what the author calls "the three Vs": values, virtues, and vision. The identification of "values" that are held in common, even across difference, leads to the development of trust and understanding. The cultivation of "virtues"--the abilities and ways of knowing that enable one to deal with various personalities, cultures, and experiences--enables one to maintain individual and institutional boundaries and to overcome barriers between people. The commitment to a vision of inclusive excellence inspires one to clear educational pathways and help others overcome obstacles and limitations. In this article, the author shares the importance to mentor cross-culturally and best practices for cross-cultural mentoring.