The purpose of this study was to use Fink's (2003) taxonomy of significant learning to redesign courses and assess student learning. Significant improvements were found across the semester for students in the six courses, but there were differences in which taxa showed improvement in each course. The meta-analysis showed significant, positive changes across disciplines in the areas of foundational knowledge, application, human dimension, and learning how to learn. This study provides support for Fink's taxonomy in which significant learning can be achieved through course redesign. (Contains 3 tables.)