Health and health-related behavior play a significant role in college students' academic performance. Unhealthy students and those who engage in risky health behaviors can have problems resulting in missed classes and lower grades. This study explored college students' health perceptions and behaviors, illness, and access to health care, and examined how they varied with respect to demographic characteristics. In a convenience survey of 397 students, data were gathered on demographics (gender, race, living arrangements, and age) as well as selected health-related behaviors, access to healthcare, and perceptions of health and the extent to which health issues impacted academic success. Females and African Americans were more likely to spend more time on social media and have poor sleep patterns. Students who lived on campus reported less fruit and vegetable intake, greater social media involvement, and lower levels of overall health than those living off campus. African American and non-traditional students were more likely to be without health insurance. Several issues were perceived to negatively impact academic success including anxiety/stress and financial difficulties. Findings help identify health issues facing subgroups of students who may be targeted by universities for support and interventions.