The main purposes of this research were twofold. We examined the samenesses about learning disabilities (LD) in Guatemala and Spain, two countries with the same language but cultural, political, and educational differences, first analyzing data about the prevalence of reading and spelling disabilities in Guatemala City and the Spanish region of the Canary Islands. The focus of the second study was to determine whether there are cross-national patterns of significant differences in cognitive processes associated with reading and spelling disabilities from a developmental approach in these two cultural contexts. We found some differences in the prevalence of specific LD in reading between both countries but we did not find significant differences between Guatemalan and Spanish reading-disabled children in cognitive processes that are involved in reading and spelling acquisition in spite of the cultural and educational differences between the two countries.