The major focus of this ethnographic study is devoted to exploring the confluence of global and local referents of science education in the context of an urban chemistry laboratory classroom taught by a first-generation Filipino-American male teacher. This study investigates encounters between the teacher and four second-generation immigrant female students of color, as well as encounters among the four students. The pervasive spread of neoliberal ideology of accountability and sanctions both globally and locally, particularly in public high schools in the Bronx, New York City fuel situations for teaching and learning science that are encoded with the referents of top-down control. In the face of theses challenges, classroom participants must become aware of productive ways to build solidarity and interstitial culture across salient social boundaries, such as age, gender, ethnicity and role, to create and sustain successful teaching and learning of chemistry. Empirical evidence for solidarity was guided by physical and verbal displays of synchrony, mutual focus, entrainment, and emotional energy, body gestures, and prosody markers. This study shows that classroom participants used a combination of prosody markers to appropriate resources to decrease breaches in face-to-face encounters and, at the same time, create and sustain participation and solidarity to successfully complete an acid-base experiment.