Misconceptions are a barrier to understanding biology hence, to promote meaningful learning, it is necessary to overcome these difficulties with the help of different instructional methods rather than traditional instructional methods. Therefore it could be very interesting to find out "how students' prior knowledge of genetics affects genetic knowledge of pupils during class education?" The preliminary investigations have been shown that usually the students have some difficulties in understanding the microscopic level of genetic topics: such as the fertilization process and its products, the genetic variation, the mitotic cell cycle, and the meiotic cell cycle. The findings of this study have been shown that students mostly have fragmented basic genetic knowledge at the beginning of the teaching process. They have basic understanding of DNA, genes and chromosomes, but lack detail. It could be interesting to work out if students' previous knowledge about genetic concepts education could affect their knowledge in genetics permanently.