The literature indicates that glucose deprivation, dehydration, decreased sleep quality and quantity, and mood changes, independently and adversely can influence cognitive functions and therefore learning. The Ramadan fast is an annual religious act undertaken by Muslims where individuals refrain from consuming food and fluid during daylight hours, daily over 30 days. Alteration in eating times and sleep-wake cycles lead to a disruption in the body's daily circadian rhythm resulting in sleep perturbations and mood swings. Consequently, Ramadan fasting is linked to daytime lower glucose concentration, dehydration, decreased sleep quality and quantity, mood swings and elevated subjective feelings of fatigue and malaise. This review highlights how Ramadan fasting potentially poses learning difficulties as a result of the independent and/or combined effects of these factors.