The study highlighted the Nigerian Universities' new sustainable development strategies: emphasizes the role that entrepreneurship education can play in both raising awareness among young people about sustainable development and giving them the skills to put sustainable development into practice. Universities place priority on the development of sustainability as "core competence" among graduates especially in this era of unemployment in our country, Nigeria. It taps its motivation from the fact that many Nigerians are becoming worried about youth unemployment. There is therefore need for the improvement of our University curriculum to meet the global challenges of wealth creation. The cardinal objective of this reform is enhanced through human capital resources development, which in turn will impact positively on growth and thus bring about reduction in poverty. There is therefore, need to develop strategies on how to create new employment opportunities and encourage technically skilled workers to develop entrepreneurship skills and be creative in their own employment. The population for this study was one thousand (1000) undergraduates in the University of Calabar. This paper is a case study of the University of Calabar. Thus, it reviewed the curriculum in University of Calabar and advocates the inclusion of entrepreneurship education in all Faculties as a means of sustainable development in Higher Education in Nigeria. The study investigated access to entrepreneurship education in University of Calabar from 2005-2010 sessions. The study also sought to find current level of production and enrolment in entrepreneurship education in all the faculties. Three research questions were drawn to direct the study. The study revealed that University of Calabar began offering entrepreneurship studies as a general course (GSS) following NUC'S mandate in 2007. However, the emphasis was in theory and not practice. The study also showed very poor attitude towards entrepreneurship education on the part of the students since emphasis is more on theory than practice. There were no entrepreneurship centre for practical, no skilled manpower, thus the awareness was very low and poor. Recommendations include that the management of University of Calabar should set a massive enlightenment campaign to popularize the subject.