Entrepreneurship is reaching new areas in which the concept of business is more or less unfamiliar and remote. This study focuses on a specific entrepreneurship education programme in the fields of chemistry, physics, information technology and bioinformatics, life sciences and medicine development. The aim is to gain a deeper understanding of the entrepreneurship-directed educational approach in a programme targeted at a special academic group with a background in natural science. The authors discuss the entrepreneurial intentions and expectations of the participants and the results of the programme as perceived by the students in the final evaluation session. They also briefly discuss the programme and the entrepreneurial-directed approach in the context of the literature on entrepreneurship training. Highlighting the key success factors, the authors then offer insights into the further development of entrepreneurship programmes for specialized academic target groups. (Contains 2 figures.)