Inhalant and prescription medication abuse, particularly among adolescents, are serious problems in our society. Several risk factors associated with inhalant and medication abuse among adolescents have been identified. As a result, adolescents may suffer multiple consequences in a range of developmental areas. The purpose of this article is to examine in-depth the prevalence, risk factors, and consequences associated with inhalant and prescription medication abuse among adolescents. Recommendations in the prevention and intervention of inhalant and prescription medication abuse are provided.