People with learning disabilities are among the most socially excluded in society. There is a significant gap in research evidence showing how health and social care workers can intervene to improve the social participation of adults with learning disabilities. A systematic review and modified narrative synthesis was used to appraise the quality and outcomes of published studies in this area. Six of eleven included studies showed a positive effect on social participation. Interventions included person-centred planning, alteration of activity patterns, a befriending scheme and skill-based group sessions. The majority of studies were found to have a moderate risk of bias. Further evidence about the effectiveness of interventions is required to inform policy and practice.