ERIC Number: EJ805636
Record Type: Journal
Publication Date: 2006
Pages: 10
Abstractor: As Provided
ISBN: N/A
ISSN: ISSN-1087-0547
EISSN: N/A
A Randomized, Double-Blind, Placebo-Controlled, Laboratory Classroom Assessment of Methylphenidate Transdermal System in Children with ADHD
McGough, James J.; Wigal, Sharon B.; Abikoff, Howard; Turnbow, John M.; Posner, Kelly; Moon, Eliot
Journal of Attention Disorders, v9 n3 p476-485 2006
Objective: This study evaluates the efficacy, duration of action, and tolerability of methylphenidate transdermal system (MTS) in children with ADHD. Method: Participants were dose optimized over 5 weeks utilizing patch doses of 10, 16, 20, and 27 mg applied in the morning and worn for 9 hours. Following optimization, 80 participants were randomized to 1 week of MTS or placebo followed by 1 week of the opposite treatment. Laboratory classroom sessions conducted after each randomized week included blinded ratings of attention, behavior, and academic performance. Results: MTS was well tolerated and displayed significant improvement compared with placebo. Improvements were seen at the first postdose time point measured and continued through 12 hours. Conclusions: Treatment with MTS resulted in statistically significant improvements on all efficacy measures. Time course and therapeutic effects of MTS suggest that this novel methylphenidate delivery system is an efficacious once-daily treatment for ADHD. (Contains 6 tables and 3 figures.)
Descriptors: Behavior Change, Delivery Systems, Attention Deficit Disorders, Hyperactivity, Drug Therapy, Symptoms (Individual Disorders), Severity (of Disability), Academic Achievement, Student Behavior, Children, Outcomes of Treatment, Rating Scales, Self Efficacy
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Publication Type: Journal Articles; Reports - Evaluative
Education Level: N/A
Audience: N/A
Language: English
Sponsor: N/A
Authoring Institution: N/A
Grant or Contract Numbers: N/A