Inter-organisational partnerships are widely used approaches in public health and chronic disease prevention (CDP), and may include organisations from different sectors, such as research-policy-practice sectors, inter-governmental sectors, or public and private sectors. While multiple conceptual frameworks related to multi-sectoral partnerships exist, they do not reflect the interactions among key factors that influence the performance of partnerships, including those involving public-private partners for CDP. Using system mapping, this project sought to propose potential linkages among factors that influence multi-sectoral partnerships through blending insights from conceptual frameworks with the experiences of a government agency involved in brokering multi-sectoral partnerships for CDP.