Suicide is the second leading cause of death in adolescents (ages 12-19) in the United States, and more work is needed to shed light on the interpersonal protective factors associated with adolescent suicidality. To address this gap in the empirical literature, we examined the application of the Interpersonal Theory of Suicide (IPTS) to the middle adolescent population. We analyzed survey data using the 2017 Oregon Healthy Teen dataset, which included 10,703 students in 11th grade. Binary logistic regressions were used to examine the extent to which the IPTS constructs of perceived burdensomeness and thwarted belongingness predicted middle adolescent suicide ideation and attempt. Findings indicate that three of the five proxy items were statistically significant in each model, with consistent mediators for each. These findings have the potential to guide development of appropriate treatment strategies based on the interpersonal constructs of the IPTS for clinicians working with this population.