Purpose: The present brain--behavior study examined whether sensory registration or neural inhibition processes explained variability in the behavioral most comfortable level (MCL) and background noise level (BNL) components of the acceptable noise level (ANL) measure. Method: A traditional auditory gating paradigm was used to evoke neural…

One important aspect of cognitive control is the ability to stop a response in progress and motivational aspects, such as self-relevance, which may be able to influence this ability. We test the influence of self-relevance on stopping specifically if increased self-relevance enhances reactive response inhibition. We measured stopping capabilities…

Fear-motivated avoidance extinction memory is prone to hippocampal brain-derived neurotrophic factor (BDNF)-dependent reconsolidation upon recall. Here, we show that extinction memory recall activates mammalian target of rapamycin (mTOR) in dorsal CA1, and that post-recall inhibition of this kinase hinders avoidance extinction memory persistence…

Virtual reality (VR) is the computer simulation of a three-dimensional environment that a person can interact with using special electronic equipment, such as a headset with an integrated display. Often coupled with VR, exergames are video games that involve physical exercise. Little is known regarding the chronic effects of exergaming through VR…

This study examined the associations between excessive alcohol intake during adolescence and neurocognitive functioning in young adulthood and whether these relations varied by sex. Participants were working-class Chilean adolescents (N = 692; M[subscript age] 16.0 years; 54.5% female) who provided frequency of past 30-day bingeing and past-year…

Recent meta-analytic work has highlighted lower creativity in schizophrenic patients as compared to control participants, but the cognitive and affective underpinnings of this difference still need to be fully understood. To this purpose, we adopted a multi-measure approach and compared a group of schizophrenic outpatients and a group of…

Longitudinal associations between signaled night awakening and executive functioning (EF) at 8 and 24 months in children with ([greater than or equal to] 3 awakenings, n = 77) and without parent-rated fragmented sleep ([less than or equal to] 1 awakening, n = 69) were studied. EF was assessed with the Switch task at 8 and 24 months. At 24 months,…

Signaled active avoidance (SAA) behavior requires the suppression of defensive reactions, such as freezing, that conflict with the avoidance response. The neural mechanisms of this inhibitory process are not well understood. Here, we demonstrate that ventromedial prefrontal cortex projections to the nucleus reuniens of the thalamus are recruited…

Children with ADHD show deficits in executive functioning, especially the ability to inhibit inadequate responses, and deficits in motivational processes due to dopaminergic dysfunctions. There is evidence that rewards can foster inhibition in children with ADHD. However, most studies examined a wide age range of children above 7 years of age, so…

Background: Early literacy and numeracy skills are developed during early childhood. Among the many factors that influence the development of such skills, the literature shows that the executive functions, especially the response inhibition (RI)--that is the capability to block out or to tune out what can be considered irrelevant information or…

This manuscript aimed to advance our understanding of inhibitory control (IC) in autism spectrum disorders (ASD), adopting a meta-analytic multilevel approach. The first meta-analysis, on 164 studies adopting direct measures, indicated a significant small-to-medium (g = 0.484) deficit in the group with ASD (n = 5140) compared with controls (n =…

This study investigated the cognitive effect of a unified flag football program in young adults with intellectual disabilities (ID). Twelve participants practiced football drills with their typical peers for 50 min each session, twice a week for 15 weeks. Measures of three aspects of executive functions (e.g., verbal working memory, measured as…

Purpose: Functional imaging is often used to try to elucidate the pathophysiological mechanism of tinnitus. Residual inhibition, the temporary suppression of tinnitus after application of a masking noise, could be an interesting technique to modulate tinnitus perception in functional imaging paradigms. The purposes of this study were to primarily…

Driving is a high-risk and cognitively demanding activity that requires the efficient use of cognitive resources to inhibit responses when necessary to avoid accidents. Cue utilization, via an inherent capacity for pattern recognition, is one strategy that may be applied while driving to reduce cognitive load allowing for the allocation of…

Purpose: Auditory sensory gating is a neural measure of inhibition and is typically measured with a click or tonal stimulus. This electrophysiological study examined if stimulus characteristics and the use of speech stimuli affected auditory sensory gating indices. Method: Auditory event-related potentials were elicited using natural speech,…