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Radiske, Andressa; Gonzalez, Maria Carolina; Nôga, Diana A.; Rossato, Janine I.; Bevilaqua, Lia R. M.; Cammarota, Martín – Learning & Memory, 2021
Fear-motivated avoidance extinction memory is prone to hippocampal brain-derived neurotrophic factor (BDNF)-dependent reconsolidation upon recall. Here, we show that extinction memory recall activates mammalian target of rapamycin (mTOR) in dorsal CA1, and that post-recall inhibition of this kinase hinders avoidance extinction memory persistence…
Descriptors: Memory, Fear, Brain Hemisphere Functions, Recall (Psychology)
Oberländer, Kristin; Witte, Victoria; Mallien, Anne Stephanie; Gass, Peter; Bengtson, C. Peter; Bading, Hilmar – Learning & Memory, 2022
Differences in the learning associated transcriptional profiles between mouse strains with distinct learning abilities could provide insight into the molecular basis of learning and memory. The inbred mouse strain DBA/2 shows deficits in hippocampus-dependent memory, yet the transcriptional responses to learning and the underlying mechanisms of…
Descriptors: Learning, Memory, Animals, Research
Yokose, Jun; Marks, William D.; Yamamoto, Naoki; Ogawa, Sachie K.; Kitamura, Takashi – Learning & Memory, 2021
Temporal association learning (TAL) allows for the linkage of distinct, nonsynchronous events across a period of time. This function is driven by neural interactions in the entorhinal cortical-hippocampal network, especially the neural input from the pyramidal cells in layer III of medial entorhinal cortex (MECIII) to hippocampal CA1 is crucial…
Descriptors: Associative Learning, Brain Hemisphere Functions, Neurological Organization, Stimuli
Briggs, Sherri B.; Hannapel, Reilly; Ramesh, Janavi; Parent, Marise B. – Learning & Memory, 2021
Research into the neural mechanisms that underlie higher-order cognitive control of eating behavior suggests that ventral hippocampal (vHC) neurons, which are critical for emotional memory, also inhibit energy intake. We showed previously that optogenetically inhibiting vHC glutamatergic neurons during the early postprandial period, when the…
Descriptors: Neurological Organization, Brain Hemisphere Functions, Inhibition, Energy
Moscarello, Justin M. – Learning & Memory, 2020
Signaled active avoidance (SAA) behavior requires the suppression of defensive reactions, such as freezing, that conflict with the avoidance response. The neural mechanisms of this inhibitory process are not well understood. Here, we demonstrate that ventromedial prefrontal cortex projections to the nucleus reuniens of the thalamus are recruited…
Descriptors: Brain Hemisphere Functions, Coping, Responses, Inhibition
Bisaz, Reto; Bessières, Benjamin; Miranda, Janelle M.; Travaglia, Alessio; Alberini, Cristina M. – Learning & Memory, 2021
Episodic memories formed during infancy are rapidly forgotten, a phenomenon associated with infantile amnesia, the inability of adults to recall early-life memories. In both rats and mice, infantile memories, although not expressed, are actually stored long term in a latent form. These latent memories can be reinstated later in life by certain…
Descriptors: Recall (Psychology), Infants, Long Term Memory, Adults
Fujii, Satoshi; Yamazaki, Yoshihiko; Goto, Jun-ichi; Fujiwara, Hiroki; Mikoshiba, Katsuhiko – Learning & Memory, 2020
In CA1 neurons of guinea pig hippocampal slices, long-term potentiation (LTP) was induced in field excitatory postsynaptic potentials (EPSPs) or population spikes (PSs) by the delivery of high-frequency stimulation (HFS, 100 pulses at 100 Hz) to CA1 synapses, and was reversed by the delivery of a train of low-frequency stimulation (LFS, 1000…
Descriptors: Brain, Animals, Brain Hemisphere Functions, Stimuli
Miller, Dylan B.; Rassaby, Madeleine M.; Collins, Katherine A.; Milad, Mohammad R. – Learning & Memory, 2022
Fear is an adaptive emotion that serves to protect an organism against potential dangers. It is often studied using classical conditioning paradigms where a conditioned stimulus is paired with an aversive unconditioned stimulus to induce a threat response. Less commonly studied is a phenomenon that is related to this form of conditioning, known as…
Descriptors: Inhibition, Conditioning, Cues, Stimuli
Wong, J. Y. Hilary; Wan, Bo Angela; Bland, Tom; Montagnese, Marcella; McLachlan, Alex D.; O'Kane, Cahir J.; Zhang, Shuo Wei; Masuda-Nakagawa, Liria M. – Learning & Memory, 2021
Discrimination of sensory signals is essential for an organism to form and retrieve memories of relevance in a given behavioral context. Sensory representations are modified dynamically by changes in behavioral state, facilitating context-dependent selection of behavior, through signals carried by noradrenergic input in mammals, or octopamine (OA)…
Descriptors: Human Body, Olfactory Perception, Animal Behavior, Memory
Engin, Elif; Sigal, Maksim; Benke, Dietmar; Zeller, Anja; Rudolph, Uwe – Learning & Memory, 2020
Reduction in the expression or function of [alpha]5-subunit-containing GABA[subscript A] receptors ([alpha]5GABA[subscript A]Rs) leads to improvement in several hippocampus-dependent memory domains. However, studies thus far mostly lack anatomical specificity in terms of neuronal circuits and populations. We demonstrate that mice with a selective…
Descriptors: Brain Hemisphere Functions, Memory, Animals, Spatial Ability
Hippocampal Efferents to Retrosplenial Cortex and Lateral Septum Are Required for Memory Acquisition
Opalka, Ashley N.; Wang, Dong V. – Learning & Memory, 2020
Learning and memory involves a large neural network of many brain regions, including the notable hippocampus along with the retrosplenial cortex (RSC) and lateral septum (LS). Previous studies have established that the dorsal hippocampus (dHPC) plays a critical role during the acquisition and retrieval/expression of episodic memories. However, the…
Descriptors: Learning Processes, Memory, Brain Hemisphere Functions, Fear
Yang, Qizong; Antonov, Igor; Castillejos, David; Nagaraj, Anagha; Bostwick, Caleb; Kohn, Andrea; Moroz, Leonid; Hawkins, Robert D. – Learning & Memory, 2018
Long-term but not short-term memory and synaptic plasticity in many brain areas require neurotrophin signaling, transcription, and epigenetic mechanisms including DNA methylation. However, it has been difficult to relate these cellular mechanisms directly to behavior because of the immense complexity of the mammalian brain. To address that…
Descriptors: Memory, Animals, Genetics, Brain
Farah, Carole A.; Hastings, Margaret H.; Dunn, Tyler W.; Gong, Katrina; Baker-Andresen, Danay; Sossin, Wayne S. – Learning & Memory, 2017
Atypical PKM, a persistently active form of atypical PKC, is proposed to be a molecular memory trace, but there have been few examinations of the role of PKMs generated from other PKCs. We demonstrate that inhibitors used to inhibit PKMs generated from atypical PKCs are also effective inhibitors of other PKMs. In contrast, we demonstrate that…
Descriptors: Memory, Brain, Neurological Organization, Neurology
Jones, Meghan E.; Sillivan, Stephanie E.; Jamieson, Sarah; Rumbaugh, Gavin; Miller, Courtney A. – Learning & Memory, 2019
microRNAs (miRNAs) have emerged as potent regulators of learning, recent memory, and extinction. However, our understanding of miRNAs directly involved in regulating complex psychiatric conditions perpetuated by aberrant memory, such as in posttraumatic stress disorder (PTSD), remains limited. To begin to address the role of miRNAs in persistent…
Descriptors: Genetics, Stress Variables, Fear, Memory
Vorster, Albrecht P. A.; Born, Jan – Learning & Memory, 2017
Sleep supports memory consolidation as shown in mammals and invertebrates such as bees and "Drosophila." Here, we show that sleep's memory function is preserved in "Aplysia californica" with an even simpler nervous system. Animals performed on an inhibitory conditioning task ("learning that a food is inedible") three…
Descriptors: Sleep, Inhibition, Operant Conditioning, Memory