Objective: Confirmatory factor analysis was used to assess the factor structure of the 6-item version of the Kessler Psychological Distress Scale (K6). Methods: A subsample of emerging adults, aged 18-29 (n = 20,699), from the 2013 National Survey of Drug Use and Health were used in this study. Results: Each of the models (one-factor, two-factor depression and anxiety and second-order two-factor psychological distress by depression and anxiety) demonstrated good fit, with significant loadings on each factor. The second-order two-factor model and the two-factor model were equivalent and a better fit than the one-factor model. Conclusions: Findings suggest that researchers and practitioners may confidently use the K6 to screen for psychological distress symptoms within the emerging adult population.