This systematic review sought to understand the individual characteristics of incarcerated youth within the major risk factor domains identified by the U.S. Office of Juvenile Justice and Delinquency Prevention (OJJDP). A comprehensive search of the literature from 1979 to 2013 identified 85 articles of individual-level risk characteristics that relate to mental health, personality, psychological factors, social/emotional-behavioral issues, cognitive-intellectual development, academic achievement, victimization history, and substance use. Understanding the characteristics that place youth at risk of incarceration is important in the development and implementation of effective educational interventions to prevent incarceration and rehabilitate incarcerated youth. Considerations regarding how educators can use a multi-tiered prevention system to deliver a continuum of academic and behavioral supports to target students' risk characteristics are discussed. In addition, future research is highlighted in response to the characteristics that place youth at risk of incarceration.