Learning is crucial for everyone. The association between biological (eg, sleep, nutrition) and psychological factors (eg, test anxiety, goal orientation) and learning performance has been well established for children, adolescents and college students in traditional education. Evidence for these associations for adult distance students is lacking however. The Adult Learning Open University Determinants (ALOUD) study is the first to identify the determinants of learning performance within adult distance education. Over the course of 1 year, all new students (n?=?4945) of the Open University of the Netherlands were approached. At baseline, 2040 students fully participated in this observational longitudinal study by filling out an online questionnaire and performing cognitive tests. At the 7 and 14 months follow-up, participants filled out a second and third questionnaire respectively, and data were given by the exam registration office to measure learning performance at these times. The ALOUD study might result in tailor-made educational innovations for adults participating in distance education and, finally, a more successful distance education student population.