The study investigated the effects of reciprocal peer tutoring in the enhancement of career decision making process among secondary school adolescent students. The interaction of sex with treatment on career decision making process of secondary school adolescent students was also investigated. 120 students from two co-educational secondary schools in Effurun, Delta State Nigeria participated in the study. A 40 item, 5 point Likert scale (Career Decision Making Process Scale) was the instrument used to obtain information from the respondents on the effect of the treatment programme on their career decision making process. Results indicate that subjects in the treatment group benefited significantly from the treatment programme. Consequently there was a significant difference in their career decision making process at post-test. Furthermore, results also indicated that there was no significant effect of sex on treatment outcome at post-test. This meant that sex had no significant impact on the career decision making process of subjects in the treatment group at post-test. This study therefore provides evidence that reciprocal peer tutoring is an effective intervention strategy for enhancing the career decision making process of secondary school adolescents. It also recommended that reciprocal peer tutoring be introduced into the school system because of the immense benefits to the students. (Contains 4 tables.)