Prenatal alcohol exposure can result in fetal alcohol spectrum disorders (FASD), which can include physical and neurobehavioral disorders, including cognitive, social, language, and motor impairments that can persist throughout life. In order for children with FASD to receive the full benefit of services, recognition of their disability needs to be made earlier and more accurately than is common today. Early identification of an FASD helps to focus targeted treatments, reduce unnecessary medical steps and redundancy in medical care, and increase the likelihood of efficacious interventions. This article describes an innovative, brief screening tool designed to test the feasibility of screening for FASD risk in early intervention (EI) settings. Feasibility was demonstrated by a screening rate of 1161 (61%) of the 1896 available children. The primary resources needed for implementing FASD screening in EI programs are a brief FASD Screening Tool, an FASD trainer, and training time. Replication efforts would benefit from cost-free cross-training between EI sites and designated pediatricians/diagnosticians who are interested in improving their skills around FASD, and development of linkages with alcohol use disorder outpatient/assessment programs for possible referrals for birth mothers. The authors assert that it is practical and feasible to screen children for FASD in EI settings. (Contains 4 tables and 2 figures.)