This article presents the results of a study on the relationship of acculturation profiles of Russian-speaking immigrants in Belgium, the duration of their stay, and their socio-economic adaptation. The data came from a socio-psychological survey of 132 Russian-speaking immigrants in Belgium (first generation) and were processed using latent profile analysis. We found three latent groups with differing acculturation profiles, largely resembling integration, assimilation, and separation. We found that a more positive orientation towards the host society (assimilation and integration) was associated with more socio-economic adaptation; moreover, the group with an assimilation profile was more adapted than the group with an integration profile. Also, the level of socio-economic adaptation was higher for immigrants who have stayed in the host country for more than five years.