A laboratory practical examination was used to compare the investigative skills developed in two different types of general-chemistry laboratory courses. Science and engineering majors (SEM) in the control group used a traditional verification approach (SEM-Ctrl), whereas those in the treatment group learned from an innovative, inquiry-based approach (SEM-Trt). A scoring rubric was developed from their examination sheets to assess six component investigative skills. Results indicated that SEM students in the SEM-Trt group scored significantly higher than those in SEM-Ctrl for all six skills. Furthermore, nursing and applied science majors (NonSEM) in the inquiry-based group (NonSEM-Trt) wrote significantly better discussions than did SEM students in SEM-Ctrl group. Overall, competency at the mid-range level of laboratory skills was attained by most SEM-Trt students (72.5%) but by only 30.5% of SEM-Ctrl and 28.6% of NonSEM-Trt students. Apparently, during the semester students in the SEM-Trt group were able to use the inquiry-based method effectively to combine chemical tasks with writing tasks and postlaboratory discussions. One implication of this study for science instructors is that practical examinations can provide useful feedback regarding the quality of the laboratory experience. Another implication is that this study provides evidence for the use of the innovative inquiry-based laboratory approach to support student learning of high-level investigative skills. However, students' requisite background knowledge must match the level of these skills.