The goal of safely and sustainably reopening K-12 school buildings for in-person learning is widely recognized as critical to minimizing the impact of academic, social, emotional, and mental strains brought forth by the COVID-19 pandemic. In order for in-person learning to succeed on an ongoing basis, schools must be able to offer safe environments, taking into account high levels of community spread of COVID-19. Health and safety are foundational for learning and educating. Scientific research and case studies have shown that robust, school-based infection prevention and control (IPC) programs are essential to establishing this solid foundation. Infection prevention and control consists of a set of practices to reduce the risk of disease transmission and achieve healthy and safe workplaces. By providing layered protection strategies, IPC programs can reduce transmission to at or near zero levels, even where there is high community spread. With the knowledge of "what" to do now clearly articulated by the Centers for Disease Control and Prevention (CDC) and scientific experts, implementing this function effectively for K-12 schools now requires focusing on "who" should do the work of infection prevention and control and "how" it should get done. This Roadmap provides general guidance on these questions, with a focus on building organizational capacity. The Roadmap is structured with the twin understandings that state and local governmental structures and labor-management collaboration take many forms and can differ between and within states, and that, to be effective, IPC initiatives must be shaped to align with those contexts. [This report was co-produced by COVID Collaborative, Harvard's Safra Center for Ethics, and Brown School of Public Health. Support for this publication was provided by Rios Partners.]