The need for a variety of practice approaches and practice activities for social workers in the schools is a priority. The purpose of the current exploratory-descriptive study was to examine the roles of school social workers (N = 378) and the ways these roles change in different school employment settings and with different caseload sizes. Predictors of the types of practice approaches and practice activities used in different school employment settings and with different caseload sizes were identified. The population of Louisiana school social workers who participated in the study completed an online or mailed survey regarding their practice of school social work. Ordered logit analyses were conducted to determine which variables predicted the use of certain practice approaches and practice activities. Findings show that caseload size had the most significant impact on practice approaches and practice activities. Additional findings regarding specific employment setting and demographic variables also showed significance. Implications for social work practice, education, and research will be discussed.