Assisting transgender individuals is a concern for career development practitioners because there is a lack of knowledge on this topic. The complexity of gender reassignment surgery brings challenges and unique needs to this population, throughout gender transition, and requires career development practitioners to understand these challenges and needs to provide appropriate services to transgender individuals. The author conducted a comprehensive review of the literature in the areas of transgender issues in career development and counseling, counseling transgender individuals, gender transition, and multicultural counseling competencies. The role of career development practitioners as advocates for transgender individuals who experience gender transition is discussed.